Concurrent transposon engineering and CRISPR/Cas9 genome editing of primary CLL-1 chimeric antigen receptor–natural killer cells

Mark Gurney,Eimear O'Reilly,Sarah Corcoran,Sarah Brophy,Janusz Krawczyk, Neil M. Otto,David L. Hermanson,Richard W. Childs,Eva Szegezdi,Michael E. O'Dwyer

Cytotherapy（2022）

引用 5|浏览19

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摘要

This report contributes a promising application of transposon engineering to donor-derived NK cells and emphasizes the importance of feeder mediated NK cell activation and expansion to current protocols.

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关键词

CAR-NK cells,CRISPR/Cas9,DNA transposon,Genome editing

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