Targeting N6-Methyladenosine Reader YTHDF1 Promotes Second Near-Infrared Nano-Photothermal Immunotherapy

Yangyang Du,Xinlun Dai,Mingda Han,Zhihua Wang,Yiqiao Wang,Zhan Shi,Fei Yan,Shouhua Feng

Chemical Engineering Journal（2022）

引用 5|浏览10

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摘要

•A nano-epigenetic therapeutic platform for photothermal immunotherapy is constructed.•Nanoplatform controls m6A methylation-based epitranscriptomic.•Nanoplatform overcomes the thermo-resistance and enhances photothermal performance.•Nanoplatform improved cross-presentation and cross-priming of CD8+ T cells.•Nanoplatform inhibits tumor metastases and induces long-term immune memory.

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关键词

YTHDF1,M6A mRNA methylation,Gold nanorod,Photothermal immunotherapy,NIR-II

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