Phoslactomycins Revisited: Polyketide Tetrahydrofurans and Lactones from an Australian Wasp Nest-Derived Streptomyces sp. CMB-MW079.

Molecular network analysis of sp. CMB-MW079 detected rare phosphorylated natural products. Miniaturized cultivation profiling (MATRIX) established optimal conditions for the production, isolation, and identification of the polyketide δ-lactone phoslactomycin E () and new ester homologues, phoslactomycins J and K ( and ), as well as unprecedented heterocyclic analogues, the tetrahydrofuran cyclolactomycins A-D (-) and γ-lactone isocyclolactomycins A-C (-). We propose a biogenetic relationship linking these cometabolites with the known lactomycins A-C which were tentatively identified as minor cometabolites.