Exploring the Mechanism of the Baishao Luoshi Formula against Poststroke Spasticity by Network Pharmacology and Experimental Validation.

Shanshan Zeng,Le Xie,Guo Mao,Yao Xie,Sijia Cao,Dong Liu,Dahua Wu

Current computer-aided drug design（2022）

Cited 1|Views8

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Abstract

our study validated that treatment with BSLSF protected against ischemic stroke via the CCR5/CREB signaling pathway and could affect synaptic plasticity. In a sense, this study provides the basis for further extensive and in-depth analysis of BSLSF, enabling the quest for new drug targets at the same time.

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Key words

CCR5,CREB,Stroke,Traditional Chinese Medicine (TCM),network pharmacology,spasticity,synaptic plasticity

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