Hygrolansamycins A-D, O -Heterocyclic Macrolides from Streptomyces sp. KCB17JA11.
Journal of microbiology and biotechnology(2022)
摘要
Six ansamycin derivatives were isolated from the culture broth of sp. KCB17JA11, including four new hygrolansamycins A-D (1-4) and known congeners divergolide O (5) and hygrocin C (6). Compounds 1-5 featured an unusual six-membered -heterocyclic moiety. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The structures of 1-4 were elucidated using NMR and HRESIMS experiments, and the absolute configuration was established by the Mosher's method. Compound 2 exhibited mild cytotoxicity against five cancer cell lines with IC values ranging from 24.60 ± 3.37 μM to 49.93 ± 4.52 μM.
更多查看译文
关键词
Molecular networking,Streptomyces,ansamycin family,hygrolansamycin
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要