Compression of the optic chiasm is associated with reduced photoentrainment of the central biological clock.

Tessel M Boertien,Eus J W Van Someren, Adriaan D Coumou, Annemieke K van den Broek,Jet H Klunder, Wing-Yi Wong, Adrienne E van der Hoeven,Madeleine L Drent,Johannes A Romijn,Eric Fliers,Peter H Bisschop

European journal of endocrinology（2022）

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Abstract

Previous optic chiasm compression due to a pituitary tumour in patients with hypopituitarism is associated with an attenuated PIPR and delayed sleep timing. Together these data suggest that ipRGC function and consequently photoentrainment of the central biological clock is impaired in patients with a history of optic chiasm compression.

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