Regioselective Perfluoroalkylation of 4-Quinolones Using Sodium Perfluoroalkyl Sulfinates

A simple and metal-free perfluoroalkylation of 4-quinolones have been developed using sodium perfluoroalkyl sulfinates and ammonium peroxodisulfate in DMSO under mild conditions. This transformation provides direct access to C-3 perfluoroalkylated 4-quinolones with broad functionality in satisfactory yields. The control experimental results suggest a radical mechanistic pathway was involved in this protocol.