Performance of p-swe and 2d-swe with three probes from a new ultrasound machine for the prediction of advanced liver fibrosis using transient elastography as a reference method

Objectives The aim of this study was to assess the performance and optimal cut-off points for p-SWE and 2D-SWE for the non-invasive assessment of advanced liver fibrosis, using transient elastography as a reference method. Materials Siemens ACUSON Sequoia (5C-1 convex transducer and Deep Abdominal Transducer-DAX) and FibroScan Compact M 530 (M and XL probes) were used. We included 198 consecutive patients with or without chronic liver disease that had all five LS values available. LS was evaluated in the same session by 3 elastographic techniques: TE, p-SWE and 2D-SWE. Reliable measurements were defined as the median value of 10 measurements and an IQR/M<0.3. For cACLD, the transient elastography cut-off point of 9.5 kPa was used [1]. Results From the 198 patients, 41.5% were women and 58.5% were men, mean age 54.8 ±13.8 years. The best cut-off values cACLD were: for 2D-SWE- 5C1 probe:>8.8 kPa, Se=97.7%, Sp=38.6%, AUC=0.84, p<0.0001;DAX probe:>7.6 kPa, Se= 40.9%, Sp=99.9%, AUC=0.84, p<0.0001; ForpSWE- 5C1 probe: >9.1 kPa, Se=54.5%, Sp=97.7%, AUC=0.86, p<0.0001; DAXprobe: > 8.8 kPa, Se=50%, Sp=98.5%, AUC=0.88, p<0.0001. Conclusions The best cut-off value for predicting cACLD in pSWE range between 8.8 kPa and 9.1 kPa and for 2D-SWE raged between 7.6 kPa and 8.8 kPa.