Ultrasonic energy for construction of bioactive heterocycles

The ultrasonic energy has been revisited and applied for the synthesis of bioactive molecules in a short time and green method. These compounds can exhibit anticancer, antioxidant, antibacterial, antimalarial, and cytotoxic properties. Some of them are organofluorines, that are widely used as potential pharmacological agents. Significantly, the synthesis of a compound having activity against SARS-CoV-2 has also been studied in this review. The complete ultrasound-assisted synthesis is catalyzed by different chemical catalysts. Ultrasonication is a promising technique for the green synthesis, rapid approach, quantitative yield of the desired molecules and brief biological importance. Among the unconventional methods, ultrasonication has drawn attention as a promising approach for the green and rapid synthesis of biological sensitive molecules in a considerable quantity.