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Lenvatinib Might Induce Activation of Host Immunity in Patients with Hepatocellular Carcinoma.

Hidenari Nagai,Takanori Mukozu,Kojiro Kobayashi, Akira Nogami,Hideki Nagumo,Kunihide Mohri,Go Watanabe,Makoto Amanuma,Naoyuki Yoshimine,Yu Ogino,Daigo Matsui,Yasuko Daido,Yasushi Matsukiyo,Teppei Matsui,Noritaka Wakui,Koichi Momiyama,Koji Higai,Takahisa Matsuda

Oncology（2023）

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Abstract
Lenvatinib might induce Th1-dominant host immunity in patients with CLD and unresectable HCC treatment in patients who showed a partial response. These changes in host immunity may be a biomarker in HCC patients treated with lenvatinib.
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Key words
Hepatocellular carcinoma,Host immunity,Lenvatinib,T helper 1/T helper 2 balance
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