Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia

Ricardo Errazquin,Angustias Page,Anna Suñol,Carmen Segrelles,Estela Carrasco,Jorge Peral,Alicia Garrido-Aranda,Sonia Del Marro,Jessica Ortiz,Corina Lorz,Jordi Minguillon,Jordi Surralles,Cristina Belendez,Martina Alvarez,Judith Balmaña,Ana Bravo,Angel Ramirez,Ramon Garcia-Escudero

Oral Oncology（2022）

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摘要

•Most oral squamous cell carcinomas from Fanconi anemia patients display FANCA and TP53 genes mutations.•Fanca-/- mutant mice display premalignant lesions in the oral mucosa.•Fanca-/-;K14cre;Trp53F2-10/F2-10 mutant mice developed oral squamous cell carcinomas with high penetrance and a latency of around 10 months.•Fanca-/- and Fanca-/-;K14cre;Trp53F2-10/F2-10 mice represent disease models for oral carcinogenesis in the context of a defective Fanconi anemia DNA repair pathway.

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关键词

Fanconi anemia,Head and neck squamous cell carcinoma,Oral squamous cell carcinoma,Mouse model,Oral mucosa,FANCA,TP53,Trp53,p53,Mutation

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