Ferroptosis contributes to hypoxic-ischemic brain injury in neonatal rats: Role of the SIRT1/Nrf2/GPx4 signaling pathway.

Chang Li,Ziyi Wu,Hang Xue,Qiushi Gao,Yahan Zhang,Changming Wang,Ping Zhao

CNS neuroscience & therapeutics（2022）

引用 16|浏览16

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摘要

The results demonstrated that during HIBI, ferroptosis occurs via the SIRT1/Nrf2/GPx4 signaling pathway, suggesting it as a potential therapeutic target for inhibiting ferroptosis and ameliorating HIBI-induced cognitive impairments.

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关键词

ferroptosis,glutathione peroxidase 4,hypoxic-ischemic brain injury,learning and memory impairments,resveratrol

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