Antitumor potential of novel 5α,6β-dibromo steroidal D-homo lactone

Ivana Z. Kuzminac,Sofija S. Bekić,Anđelka S. Ćelić,Dimitar S. Jakimov,Marija N. Sakač

Steroids（2022）

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摘要

•New steroidal D-homo-3β-hydroxy-5α,6β-dibromo androstane derivative was synthesized.•New steroid compound showed cytotoxic activity against HT-29 and A549 cell lines.•Novel compound has the potential to induce apoptosis in HT-29 cells.•Ligand binding assay suggested a lack of significant estrogenic or androgenic properties.

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% Abs,A549,ADME,AR,BBB,Ctrl,DMSO,ER,FRET,HBA,HBD,HeLa,HIA,HT-29,LBD,LogP,MCF-7,MDA-MB-231,mp,MR,MRC-5,MW,nrotb,PC3,PGP,TPSA,YFP

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