Helix: An Electrochemical CMOS DNA Synthesizer

Omid Ghadami,Hongyu Lu,Matthew Chan, Mila Tan,Saeromi Chung,Sang Heon Lee,Matthew T. Holden, Ryan de Ridder,Barry Merriman,Drew A. Hall

2022 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)（2022）

Cited 4|Views26

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Abstract

This work describes the highest feature density CMOS-based DNA synthesizer, where individually addressable sub-μm pixels generate acid in situ for deprotection. A new redox chemistry enables this at low voltages. Implemented in 65nm CMOS, electrodes as small as 0.6μm ² were implemented, and oligos up to 100 nucleotides (nt) were synthesized.

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Key words

helix,electrochemical CMOS DNA synthesizer,highest feature density CMOS-based DNA synthesizer,individually addressable sub-μm pixels,redox chemistry,size 65.0 nm

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