High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing.

Sacha Spelier,Eyleen de Poel, Georgia N Ithakisiou, Sylvia W F Suen,Marne C Hagemeijer,Danya Muilwijk,Annelotte M Vonk, Jesse E Brunsveld,Evelien Kruisselbrink,Cornelis K van der Ent,Jeffrey M Beekman

Journal of Cystic Fibrosis（2023）

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摘要

Future studies should focus on elucidating genotype specificity and mode-of-action of statins in more detail. This study exemplifies proof of principle of large-scale compound screening in a functional assay using patient-derived organoids.

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关键词

functional assay,organoids,drug repurposing,high-throughput,patient-derived

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