Experimental study on the anti-inflammatory effect of Mongolian medicine Sendeng Decoction on mice with psoriasis

Psoriasis is a chronic papulosquamous skin disease occurring worldwide caused by varieties of factors. The recipe of Mongolian medicine Sendeng Decoction was recorded in “The Pleasure of the Viewer” compiled by Jigwood Danjinzhamusu. Mongolian medicine clinical experience proved that Sendeng Decoction had good antipyretic, analgesic, anti-inflammatory and anti-rheumatism effect. However, the mechanism of this drug in psoriasis is still unclear. In this study, imiquimod cream (IMQ) was used to construct psoriasis model in 8-week-old male BALB/c mice, and Sendeng Decoction was used to treat the mice with psoriasis. The results showed that PASI score and spleen index decreased after Sendeng Decoction treatment. Meanwhile, HE staining showed that the pathological structure was improved, flow cytometry results showed that the proportion of Treg cells increased and Th17 ​cells decreased, and results of Western blot showed that the level of p38 MAPK, p-p38 MAPK, p-STAT3 and p-JAK1 decreased observably. More importantly, the above results were most significant in Sendeng's M group, which was similar to MTX group. Our results indicated that Mongolian medicine Sendeng Decoction can effectively relieve the symptoms of psoriasis mice induced by IMQ, mainly by regulating the ratio of Th17/Treg cells through the JAK/STAT and p38 MAPK pathways to reduce the inflammatory state in mice, thereby improving the symptoms of dermatitis.