The impact of the surfactant type on physicochemical properties, encapsulation, and in vitro biocompatibility of coconut oil nanoemulsions
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS（2022）
Abstract
Background: This study investigated the effects of the three types of surfactants including polyethylene glycol 100-stearate (S-PEG100), hydrogenated soybean lecithin (HL), and dimethyldiocatadecylammonium (DODAB) on the physicochemical characteristics, encapsulation, and in vitro biocompatibility of coconut oil (CO) nanoemulsions (NEs). Methods: Size distribution, zeta-potential, structure, and storage stability of the CO NEs were comprehensively studied. The intra-particle and rheological properties of NEs were assessed by using differential scanning calorimetry, fluorescence polarization analysis, and viscosity measurement. The in vitro biocompatibility and the encapsulation efficiency of CO NEs emulsified with S-PEG100, HL, and DODAB were also evaluated. Significant Findings: The size order was S-PEG100-More
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Key words
Nanoemulsions,Surfactant type,Coconut oil,Physicochemical characteristics,Cytotoxicity,Encapsulation efficiency
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