Folic acid-functionalized cerium oxide nanoparticles as smart nanocarrier for pH-responsive and targeted delivery of Morin in breast cancer therapy

Neelam Thakur,Pritam Sadhukhan,Mousumi Kundu,Th. Abhishek Singh,Madushmita Hatimuria,Ashok Pabbathi,Joydeep Das,Parames C. Sil

Inorganic Chemistry Communications（2022）

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摘要

•A novel FA-tagged CeO2NPs were synthesized for targeting human breast cancer cells.•The NPs were loaded with morin, a natural flavonoid to form Morin-CeO2-NH-FA nanohybrids.•Morin-CeO2-NH-FA nanohybrids exhibited pH-dependent drug release property.•Morin-CeO2-NH-FA nanohybrids showed significant anticancer effect both in vitro and in vivo.•Morin-CeO2-NH-FA nanohybrids did not exhibit any systemic toxicity.

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关键词

Anticancer,Apoptosis,Morin,Nanoceria,Reactive oxygen species,Targeted drug delivery

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