Pharmacokinetics and Early Tumor Response to Conventional Transarterial Chemoembolization with Sorafenib and Doxorubicin in a VX2 Rabbit Tumor Model

Lobna Elkhadragy,Ramzy C Khabbaz,Ruth N Muchiri,William M Totura,Jonathan P Samuelson,Herbert E Whiteley,Richard B van Breemen,R Peter Lokken,Ron C Gaba

Journal of Vascular and Interventional Radiology（2022）

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摘要

The addition of sorafenib to DOX-TACE delivered to VX2 liver tumors resulted in high intratumoral and low systemic concentrations of sorafenib without altering the PK of doxorubicin.

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AUC,Cmax,DOX,HCC,HIF-1α,IC50,IQR,MVD,PK,SORA-DOX,TACE,VEGF

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