Interventional cytopathologist can successfully combine ultrasonographical and microscopic skills to narrow the differential diagnosis in fine needle aspiration of neck paraganglioma.

The interventional cytopathologist can successfully refine the differential diagnosis of a neck mass by combining ultrasonographical and morphological skills as shown in this case of head and neck paraganglioma, which was suspected thanks to ultrasound features and rapid-on site evaluation and further confirmed by immunocytochemistry on cell block and by the subsequent histologic evaluation.