Indole alkaloids fusarindoles A–E from marine-derived fungus Fusarium equiseti LJ-1

Five undescribed indole alkaloids, fusarindoles A–E, together with seven known compounds were obtained from the marine-derived fungus Fusarium equiseti LJ-1. Their chemical structures and absolute configurations were determined by comprehensive analysis of the NMR, HRMS, UV, IR, ECD calculation and single-crystal X-ray diffraction data. The possible biosynthetic pathways of fusarindoles C–E were proposed. The cytotoxicities of eleven compounds, including fusarindoles A–E and six known compounds, against five human cancer cell lines A549, CNE2, SUNE1, HepG2 and QGY7701 were evaluated.