Yeast@MOF bioreactor as a tumor metabolic symbiosis disruptor for the potent inhibition of metabolically heterogeneous tumors

•“Metabolic symbiosis” impedes the development of therapies which aim at metabolic vulnerabilities.•A yeast@MOF bioreactor has been designed as a tumor metabolic symbiosis disruptor.•The bioreactor integrates the biocompatible probiotic yeast with functional enzyme-encapsulated metal-organic-framework.•The bioreactor could disrupt metabolic symbiosis between glycolytic and oxidative tumor cells.•The bioreactor can elevate oxidative stress for further amplifying the tumor inhibition effect.