Valproic acid as a radio-sensitizer in glioma: A systematic review and meta-analysis.
Neuro-oncology practice(2023)
Abstract
This review suggests that glioma patients undergoing RT may experience prolonged survival due to HDACi VPA administration. Further randomized controlled trials are required to validate these findings. Additionally, more research into the use of HDACi radio-adjuvant treatment in non-glioma solid organ malignancies is warranted.
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Key words
central nervous system neoplasm,glioma,histone deacetylase inhibitor,radiation-sensitizing agents,valproic acid
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