Assessment of flomoxef combined with amikacin in a hollow-fibre infection model for the treatment of neonatal sepsis in low- and middle-income healthcare settings.

Christopher A Darlow,Laura McEntee,Adam Johnson,Nicola Farrington,Jennifer Unsworth,Ana Jimenez-Valverde, Bhavana Jagota,Ruwanthi Kolamunnage-Dona,Renata M A Da Costa,Sally Ellis,François Franceschi,Mike Sharland,Michael Neely,Laura Piddock,Shampa Das,William Hope

The Journal of antimicrobial chemotherapy（2022）

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摘要

We conclude that the combination of flomoxef and amikacin is synergistic and is a potentially clinically effective regimen for the empirical treatment of neonatal sepsis in LMIC settings and is therefore suitable for further assessment in a clinical trial.

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neonatal sepsis,amikacin,infection,hollow-fibre,middle-income

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