Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus, targets peptidoglycan biosynthesis

Viral Rawat, Sona Tiwari,Shweta Khanna,Umang Gupta,Sridhar S N C, Dharmendra K Yadav,Grace Kaul,Abdul Akhir,Deepanshi Saxena,Saravanan Matheshwaran,Sidharth Chopra,Dharmaraja Allimuthu

CHEMICAL COMMUNICATIONS（2022）

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摘要

Antimicrobial resistance (AMR) is a global health concern. Targetting AMR, we present an in situ lactonization mechanism generating 4-nitroisobenzofuran-1(3H)-one (IITK2020), an exclusive S. aureus inhibitor at 2-4 mu g mL(-1) MIC including multidrug-resistant S. aureus clinical strains, that prevents peptidoglycan biosynthesis.

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关键词

peptidoglycan biosynthesis,multidrug-resistant <i>staphylococcus aureus</i>,<i>staphylococcus aureus</i>,small molecule inhibitor

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