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Blockage of Wnt/β-catenin Signaling Pathway in Colorectal Cancer Resistant Cells by Nitazoxanide Effects on Peptidylarginine Deiminases Expression.

Mohsen Hemmati-Dinarvand, Shahnaz Kheirandish,Ali Khodadadian,Mostafa Mostafazadeh,Atefeh Seghatoleslam

Asian Pacific journal of cancer prevention : APJCP（2022）

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Abstract
The results showed that NTZ leads to notable upregulation of PAD2 and PAD4, which can disrupt the Wnt/β-catenin signaling pathway and reverse the MDR by reducing MDR1 and MRP1 expression.
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Multidrug Resistance,Nitazoxanide,Peptidylarginine deiminase,Wnt/β -catenin,colorectal cancer
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