RNase III-CLASH brings bacterial RNA networks into focus

Bacterial small RNAs have emerged as crucial regulators in complex networks controlling diverse phenotypes. Two groups, Mediati et al. and McKellar et al., have leveraged CLASH technology and the global regulatory potential of RNase III to build a rich landscape of RNA interactions in Staphylococcus aureus, revealing post-transcriptional control of virulence and new mechanistic themes for exploration.