Cost-Effectiveness of a Specialized Breathlessness Service Versus Usual Care for Patients with Advanced Diseases
Value in health(2023)
Abstract
Objectives: The Munich Breathlessness Service (MBS) significantly improved control of breathlessness measured by the Chronic Respiratory Questionnaire (CRQ) Mastery in a randomized controlled fast track trial with waitlist group design spanning 8 weeks in Germany. This study aimed to assess the within-trial cost-effectiveness of MBS from a societal perspective.Methods: Data included generic (5-level version of EQ-5D) health-related quality of life and disease-specific CRQ Mastery. Quality-adjusted life years (QALYs) were calculated based on 5-level version of EQ-5D utilities valued with German time trade-off. Direct medical costs and productivity loss were calculated based on standardized unit costs. Incremental cost-effectiveness ratios (ICER) and cost-effectiveness-acceptance curves were calculated using adjusted mean differences (AMD) in costs (gamma-distributed model) and both effect parameters (Gaussian-distributed model) and performing 1000 simultaneous bootstrap replications. Potential gender differences were investigated in stratified analyses.Results: Between March 2014 and April 2019, 183 eligible patients were enrolled. MBS intervention demonstrated signifi-cantly better effects regarding generic (AMD of QALY gains of 0.004, 95% confidence interval [CI] 0.0003 to 0.008) and disease-specific health-related quality of life at nonsignificantly higher costs (AMD of euro 605 [95% CI-1109 to 2550]). At the end of the intervention, the ICER was euro 152 433/QALY (95% CI-453545 to 1625903) and euro 1548/CRQ Mastery point (95% CI-3093 to 10168). Intervention costs were on average euro 357 (SD = 132). Gender-specific analyses displayed dominance for MBS in males and higher effects coupled with significantly higher costs in females.Conclusions: Our results show a high ICER for MBS. Considering dominance for MBS in males, implementing MBS on approval within the German health care system should be considered.
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Key words
breathlessness service,cost-effectiveness analysis,disease-specific health-related quality of life,gender specific,generic health-related quality of life,multidisciplinary nonmedical intervention,palliative medicine
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