Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia

Andrea Bellavia,Runyu Zou,Richelle D. Björvang,Kristine Roos,Ylva Sjunnesson,Ida Hallberg,Jan Holte,Anne Pikki,Virissa Lenters,Lützen Portengen,Jacco Koekkoek,Marja Lamoree,Majorie Van Duursen,Roel Vermeulen,Andres Salumets,Agne Velthut-Meikas,Pauliina Damdimopoulou

Environmental Research（2022）

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摘要

•We assessed a mixture of 59 chemicals in ovarian follicular fluid.•Ovarian sensitivity index (OSI) was used to measure female fertility.•DEHP metabolites and methylparaben were associated with lower OSI.•Signals of associations were also observed at higher concentrations of PFUnDA.•The overall chemical mixture was associated with lower OSI.

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关键词

Endocrine disruptors,parabens,phthalates,environmental mixtures,ovarian sensitivity index,female fertility

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