Repair of Rat Calvarial Bone Defect by Using Exosomes of Umbilical Cord-Derived Mesenchymal Stromal Cells Embedded in Chitosan/Hydroxyapatite Scaffolds.

Dilek Bahar,Zeynep Burcin Gonen,Menemse Gumusderelioglu,Mehmet Emin Onger,Elvan Konuk Tokak,Fatma Ozturk-Kup, Buket Banu Ozkan,Nur Seda Gokdemir,Mustafa Cetin

The International journal of oral & maxillofacial implants（2022）

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摘要

The CS/HA/Exo combination is a novel treatment for bone defect repair to induce bone formation. The CS scaffold can significantly promote bone regeneration compared with the control. Moreover, the combination with HA and exosomes is promising for applications in bone tissue regeneration.

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关键词

bone tissue engineering,chitosan,exosomes,mesenchymal stem cell

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