Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry "Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors"

G. P. Arutyunov,E. I. Tarlovskaya,A. G. Arutyunov,Yu. N. Belenkov,A. O. Konradi,Yu. M. Lopatin,A. P. Rebrov,S. N. Tereshchenko,A. I. Chesnikova,G. G. Airapetyan,A. P. Babin,I. G. Bakulin,N. V. Bakulina,L. A. Balykova,A. S. Blagonravova,M. V. Boldina,M. I. Butomo,A. R. Vaisberg,A. S. Galyavich,V. V. Gomonova,N. Yu. Grigorieva,I. V. Gubareva,I. V. Demko,A. V. Evzerikhina,A. V. Zharkov, A. A. Zateyshchikova,U. K. Kamilova,Z. F. Kim,T. Yu. Kuznetsova,A. N. Kulikov,N. V. Lareva,E. V. Makarova,S. V. Malchikova,S. V. Nedogoda,M. M. Petrova,I. G. Pochinka,K. V. Protasov,D. N. Protsenko,D. Yu. Ruzanov,S. A. Saiganov,A. Sh. Sarybaev,N. M. Selezneva,A. B. Sugraliev,I. V. Fomin,O. V. Khlynova,O. Yu. Chizhova,I. I. Shaposhnik, D. A. Schukarev,A. K. Abdrakhmanova, S. A. Avetisyan, O. G. Avoyan, K. K. Azaryan,G. T. Aimakhanova, D. A. Aiypova,A. Ch. Akunov,M. K. Alieva, A. R. Almukhambedova,A. V. Aparkina,O. R. Aruslanova,E. Yu. Ashina,O. Yu. Badina,O. Yu. Barysheva,T. I. Batluk, A. S. Batchaeva,R. A. Bashkinov,A. M. Bitieva, I. U. Bikhteev,N. A. Borodulina,M. V. Bragin,V. A. Brazhnik,A. M. Budu,G. A. Bykova,K. R. Vagapova,D. D. Varlamova,N. N. Vezikova,E. A. Verbitskaya,O. E. Vilkova,E. A. Vinnikova,V. V. Vustina,E. A. Galova,V. V. Genkel,D. B. Giller,E. I. Gorshenina, E. V. Grigoryeva,E. Yu. Gubareva,G. M. Dabylova,A. I. Demchenko,O. Yu. Dolgikh, M. Y. Duishobaev,D. S. Evdokimov,K. E. Egorova,A. N. Ermilova, A. E. Zheldybaeva,N. V. Zarechnova,Yu. D. Zimina,S. Yu. Ivanova,E. Yu. Ivanchenko, M. V. Ilyina,M. V. Kazakovtseva,E. V. Kazymova,Yu. S. Kalinina,N. A. Kamardina,A. M. Karachenova,I. A. Karetnikov,N. A. Karoli,M. Kh. Karsiev,D. S. Kaskaeva,K. F. Kasymova, J. B. Kerimbekova,E. S. Kim,N. V. Kiseleva,D. A. Klimenko,A. V. Klimova,O. V. Kovalishena,S. V. Kozlov,E. V. Kolmakova,T. P. Kolchinskaya,M. I. Kolyadich, O. V. Kondryakova,M. P. Konoval,D. Yu. Konstantinov,E. A. Konstantinova, V. A. Kordyukova,E. V. Koroleva,A. Yu. Kraposhina,T. V. Kryukova, A. P. Kuznetsova,T. Yu. Kuzmina,K. V. Kuzmichev,Ch. K. Kulchoroeva,T. V. Kuprina,I. M. Kuranova,L. V. Kurenkova,N. Yu. Kurchugina,N. A. Kushubakova,V. I. Levankova,A. A. Ledyaeva,T. V. Lisun, V. E. Lisyanskaya,N. A. Lyubavina,N. A. Magdeeva,K. V. Mazalov, V. I. Mayseenko,A. S. Makarova,A. M. Maripov, N. V. Markov,A. A. Marusina,E. S. Melnikov, A. I. Metlinskaya,N. B. Moiseenko,F. N. Muradova,R. G. Muradyan,Sh. N. Musaelyan,E. S. Nekaeva,N. M. Nikitina,S. E. Nifontov, E. Yu. Obolentseva,A. A. Obukhova,B. B. Ogurlieva,A. A. Odegova,Yu. V. Omarova,N. A. Omurzakova,Sh. O. Ospanova,V. A. Pavlova, E. V. Pakhomova,L. D. Petrov,S. S. Plastinina, D. A. Platonov,V. A. Pogrebetskaya,D. V. Polyakov,D. S. Polyakov,E. V. Ponomarenko,L. L. Popova,A. A. Potanin, N. A. Prokofieva,Yu. D. Rabik,N. A. Rakov,A. N. Rakhimov,N. A. Rozanova,S. Serikbolkyzy, Ya. A. Sidorkina,A. A. Simonov,V. V. Skachkova,R. D. Skvortsova,D. S. Skuridin, D. V. Solovieva,I. A. Solovieva,I. M. Sukhomlinova,A. G. Sushilova,D. R. Tagaeva,Yu. V. Titoikina,E. P. Tikhonova,D. S. Tokmin,A. A. Tolmacheva,M. S. Torgunakova,K. V. Trenogina, N. A. Trostyanetskaya,D. A. Trofimov,M. A. Trubnikova,A. A. Tulichev,A. T. Tursunova,N. D. Ulanova,O. V. Fatenkov,O. V. Fedorishina,T. S. Fil,I. Yu. Fomina,I. S. Fominova,I. A. Frolova,S. M. Tsvinger,V. V. Tsoma,M. B. Cholponbaeva,T. I. Chudinovskikh,I. V. Shavrin,O. A. Shevchenko, D. R. Shikhaliev,E. A. Shishkina,K. Yu Shishkov, S. Yu. Shcherbakov,G. V. Shcherbakova,E. A. Yausheva

Russian Journal of Cardiology（2022）

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摘要

Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry.Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation.Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of <2,45 mmol/l is significantly worse than in patients with an LDL-C level ≥2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<1,4 mmol/l), mortality was 13,04%, which was significantly higher than in patients with LDL-C ≥1,4 mmol/l (6,32%, p=0,047).Conclusion. A decrease in LDL-C in the acute period is significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. Determination of LDL-C can be included in the examination program for patients with COVID-19. However, the predictive value of this parameter requires further study in prospective clinical studies.

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关键词

covid-19,low density lipoproteins,cholesterol

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