Simvastatin attenuates glucocorticoid-induced human trabecular meshwork cell dysfunction via YAP/TAZ inactivation.

Hannah Yoo,Ayushi Singh,Haiyan Li,Ana N Strat,Tyler Bagué,Preethi S Ganapathy,Samuel Herberg

biorxiv（2023）

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摘要

YAP/TAZ inactivation with simvastatin attenuates HTM cell pathobiology in a tissue-mimetic ECM microenvironment. Our data may help explain the association of statin use with a reduced risk of developing glaucoma via indirect YAP/TAZ inhibition as a proposed regulatory mechanism.

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关键词

Mechanotransduction,TM cell pathobiology,cell-ECM interaction,cholesterol,steroid-induced glaucoma

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