Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor.

Suet-Ying Kwan, Alyssa N Slayden, Aubrey R Coronado, Rosamaria C Marquez, Huiqin Chen,Peng Wei,Michelle I Savage,Lana A Vornik,Jennifer T Fox,Shizuko Sei,Dong Liang,Heather L Stevenson, Gregory K Wilkerson,Mihai Gagea,Powel H Brown,Laura Beretta

Cancer prevention research (Philadelphia, Pa.)（2023）

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摘要

Means to prevent development of HCC or progression of small adenomas to HCC in patients with NASH are urgently needed to reduce the growing mortality due to HCC. We characterized the chemopreventive effect of oral administration of the TLR4 inhibitor TAK-242 in a model of NASH-associated HCC.

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关键词

inhibitor,treatment,nash-associated,toll-like

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