HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma

Chiyumi Oda,Kenya Kamimura,Osamu Shibata,Shinichi Morita,Yuto Tanaka,Toru Setsu,Hiroyuki Abe,Takeshi Yokoo,Akira Sakamaki,Hiroteru Kamimura,Satoshi Kofuji,Toshifumi Wakai,Hiroshi Nishina,Shuji Terai

Biochemistry and Biophysics Reports（2022）

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摘要

•HBx and YAP expression are related to the HCC size and tumor marker level.•HBx activates YAP expression and both protein expressions are correlated.•Co-expression of HBx and YAP contributes to the poor prognosis of HCC cases.•HBx and YAP expression in vitro activated various oncogenic pathways.

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关键词

HBV,HBx,YAP,Hepatocellular carcinoma

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