Non-Invasive Fetal K Status Prediction: 7 Years of Experience.

Klaus Rieneck,Frederik Banch Clausen,Thomas Bergholt,Lone Nikoline Nørgaard,Morten Hanefeld Dziegiel

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie（2022）

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摘要

We have developed an NGS-based method for the non-invasive prediction of fetal K status. This approach requires special considerations in terms of primer design, stringent preanalytical sample handling, and careful analytical procedures. We analyzed samples starting at GA 10 weeks and demonstrated the correct prediction of fetal K status. This assay enables timely clinical intervention in pregnancies at risk of hemolytic disease of the fetus and newborn caused by maternal anti-K IgG antibodies.

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关键词

Cell-free DNA,Genotyping,Hemolytic disease of the fetus and newborn,Kell blood group,Next-generation sequencing,Non-invasive prediction,Prenatal diagnosis

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