Generation and characterization of patient-derived xenografts from patients with osteosarcoma

Fei Chen,Zhenzhen Zhang,Rongkai Shen,Meng Chen,Guoping Li,Xia Zhu

Tissue and Cell（2022）

Cited 1|Views8

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Abstract

•Osteosarcoma (OS) is a kind of rare tumors with challenges in treatment.•All the xenografts were identified pathologically and genetically.•OS PDX was similar to the patient’s tumor.•PDX model showed a strong tumor inhibition effect to the combination regimen.

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Key words

Osteosarcoma,Patient-derived xenografts,Fidelity,Genetics,Pharmacodynamics

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