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Apolipoprotein E genotypes were not associated with intracranial atherosclerosis: a population-based autopsy study

Regina Silva Paradela,Daniela Souza Farias-Itao,Renata E P Leite,Carlos A Pasqualucci,Lea T Grinberg,Michel Satya Naslavsky,Mayana Zatz,Ricardo Nitrini,Wilson Jacob-Filho,Claudia Kimie Suemoto

Cardiovascular Pathology（2023）

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Abstract
•The APOE polymorphism was not associated with atherosclerosis in the 12 arteries of the Circle of Willis•Having at least one APOE-ε4 allele was not related to a high risk of intracranial atherosclerosis•Lower stenosis in older carriers of APOE-ε4 suggests the possibility of attrition bias
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Key words
Apolipoprotein E,Atherosclerosis,Cerebral arteries,Epidemiology,Risk factors
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