GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells

Yannick S Rakké,Lucia Campos Carrascosa,Adriaan A van Beek,Valeska de Ruiter,Rachelle S van Gemerden,Michail Doukas,Pascal G Doornebosch,Maarten Vermaas, Susan Ter Borg,Erwin van der Harst,Peter Paul L O Coene,Mike Kliffen,Dirk J Grünhagen,Cornelis Verhoef,Jan N M IJzermans,Jaap Kwekkeboom,Dave Sprengers

Cellular and Molecular Gastroenterology and Hepatology（2023）

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摘要

GITR is overexpressed on CD4 and CD8 TIL from pMMR CRC and CRLM. Agonistic targeting of GITR enhances ex vivo human TIL functionality and may therefore be a promising approach for novel monotherapy or combined immunotherapies in primary pMRR CRC and CRLM.

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关键词

Colorectal carcinoma,Immune Checkpoint Stimulation,Liver metastasis,Microsatellite Stable,TNF Receptor Superfamily,Tumor-Infiltrating Lymphocytes

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