Clostridium ramosum bacteremia: A case series at a general acute care hospital

Clostridium ramosum infections have been rarely reported, probably due to underestimating in clinical practice. Seven patients with bacteremia from gastrointestinal sources and skin and soft tissue were recognized between 2009 and 2020. Most of them were older and in compromised status, and they had risk factors including cancer, diabetes, liver cirrhosis, gangrene, and pressure ulcers. The source of infections was considered bacterial translocation from the gastrointestine and the skin and soft tissue infections. All patients were treated with antimicrobials, and two received surgical interventions. Four patients died secondary to sepsis due to C. ramosum. The bacteremia of C. ramosum should be appropriately evaluated and treated, especially in compromised hosts.