Identification and characterisation of the isomers of cyclothiazide responsible for potentiating ampa current.

Alex A. Cordi,Bernard Serkiz,Philippe Hennig, Jean-Pierre Mahieu,Christine Bobichon, Guillaume de Nanteuil,Jean M. Lepagnol

Bioorganic & Medicinal Chemistry Letters（1994）

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摘要

The four diastereoisomers of cyclothiazide have been separated by chromatography. The most potent fraction was split further into two enantiomers by chiral HPLC. The most active isomer is five times more potent than cyclothiazide in potentiating AMPA transmission in rat cortex mRNA injected Xenopus oocytes.

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