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d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway

Zhiming Lin,Jianing Miao,Tao Zhang, Ming He,Xiaonan Zhou,He Zhang,Yue Gao,Lunhao Bai

Biomedicine & Pharmacotherapy（2021）

Cited 11|Views14
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Abstract
•D-mannose delays osteoarthritis degeneration in IL-1β-treated rat chondrocytes.•A median dose of d-mannose suppresses osteoarthritis development in vivo.•D-mannose delays degeneration by activating autophagy in IL-1β-treated chondrocytes.•D-mannose activates autophagy by phosphorylating AMPK in IL-1β-treated chondrocytes.
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3-MA,AL,ADAMTS,AMPK,AP,CCK-8,COL2A1,DMSO,H&I,IHC,IL,LC,MIA,MMP,MRI,OA,OARSI,PI,qPCR,SD,SPF,SQSTM1,TEM
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