Electric neurostimulation regulates microglial activation via retinoic acid receptor α signaling

Smadar Goldfarb,Nina Fainstein,Tal Ganz,Dan Vershkov,Marva Lachish,Tamir Ben-Hur

Brain, Behavior, and Immunity（2021）

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摘要

•Electrical neurostimulation regulates microglia preventing their toxic activation.•This effect is mediated by the RARa signaling pathway and its related genes.•This work links electric neurostimulations with reducing innate CNS inflammation.•Presenting new therapeutic options for microglia derived neurological diseases.

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关键词

Neurostimulation,Electroconvulsive therapy (ECT),Electroconvulsive seizures (ECS),Microglia,Neurotoxicity,Neuroinflammation,Retinoic acid receptor a (RARa)

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