Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness.

Alex C H Liu,Severine Cathelin,Yitong Yang,David L Dai,Dhanoop Manikoth Ayyathan,Mohsen Hosseini,Mark D Minden,Anne Tierens,Steven M Chan

Cancer research（2022）

引用 7|浏览10

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摘要

A CRISPR knockout screen identifies a mechanism of resistance to IDH inhibitors in AML involving activated STAT5 signaling, suggesting a potential strategy to improve the clinical efficacy of IDH inhibitors.

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关键词

stat5 signaling overcomes resistance,idh inhibitors,acute myeloid leukemia,stemness

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