Effects of Imatinib Combined With Everolimus on Mouse Pituitary Tumor Cell AtT-20.

Wenxin Wang,Yi Lin,Xinguo Qu,Linghu Meng,Jianquan Yang

Alternative therapies in health and medicine（2023）

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Abstract

Imatinib combined with everolimus can affect the AtT-20 cell cycle through the signaling pathway of the phosphatidylin-ositol-3-kinase (PI3K)/Akt/ protein kinase A (PKA) system and can inhibit cell proliferation and induce cell apoptosis. Therefore, Imatinib and everolimus may be an effective combination of candidates for drugs for mouse pituitary tumor.

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Key words

everolimus,imatinib,tumor

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