A metabolic and mitochondrial angle on aging

The increasingly aged human population (mainly in developed countries) represents a significant scientific achievement and privilege associated with medical, social, and economic progress. However, it also poses several challenges to national health and social care systems. The uncoupling of biological evolution with the vast and fast technical progress achieved by humanity has minimized the role of natural selection and rendered aging almost an undesirable physiological event that most people desire to delay as much as possible. All this has been challenging modern gerontology to focus on potential strategies to extend the lifespan, but primarily to mitigate the negative thoughts often associated with aging and aged individuals.