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Clinically relevant model of oxaliplatin-induced sinusoidal obstruction syndrome.

Rei Toda,Satoru Seo,Yusuke Uemoto,Koshiro Morino,Hiroto Nishino,Naohiko Nakamura,Masayuki Okuno,Kohta Iguchi,Motohiko Sato,Kojiro Nakamura,Kojiro Taura,Shunsaku Nakagawa,Takayuki Nakagawa,Tatsuaki Tsuruyama,Toshiaki Manabe,Hiroaki Kawaguchi,Keiko Iwaisako,Masaya Ikegawa,Shinji Uemoto,Etsuro Hatano

Hepatology research : the official journal of the Japan Society of Hepatology（2023）

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Abstract
With distinct differences between monocrotaline-induced rat SOS and human/pig OXCx-SOS, our pig OXCx-SOS model serves as a preclinical platform for future investigations to dissect the pathophysiology of OXCx-SOS and seek preventive strategies.
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Key words
colorectal liver metastasis,liver sinusoidal endothelial cell,matrix metalloproteinase 9,micro-minipig,oxaliplatin,sinusoidal obstruction syndrome
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