Metabolomics variation profiling of vaginal discharge identifies potential targets for cervical cancer early warning.

Cervical cancer(CC)continues to be the second leading cause of cancer death in women aged 20 to 39[1].Recent research has shown that the cervical microbiota differs in different stages of cervical carcinogenesis[2].It has been reported that the gut microbiota is linked to host metabolism,which influences the progression of the disease[3].The role of cervicovaginal flora in affecting host metabolism,thereby causing the progression of cervical cancer,requires further research.In this direction,metabolomics has been implemented to detect small molecular differential metabolites in cancer progression.Metabolomics is the study of the thousands of low-molecular-weight molecules found in biological fluids and tissues of different individuals,whether normal or afflicted with disease,and it reflects reasonable changes in biological functions.