Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/ DICER1 Registry.

Kris Ann P Schultz,Anne K Harris,Alexander T Nelson,Dave Watson,John T Lucas,Doug Miniati,Douglas R Stewart,Kelly N Hagedorn,William Mize,Junne Kamihara,Sarah G Mitchell,David B Wilson,Katie Gettinger, Arun A Rangaswami,Laura A Harney,Carlos Rodriguez Galindo,Gianni Bisogno,Louis P Dehner,D Ashley Hill,Yoav H Messinger

Journal of clinical oncology : official journal of the American Society of Clinical Oncology（2023）

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摘要

The use of IVADo in children with type II and type III PPB resulted in similar-to-improved outcomes compared with historical controls. Inferior outcomes with metastatic disease suggest the need for novel therapies. This large cohort of uniformly treated children with advanced PPB serves as a benchmark for future multicenter therapeutic studies for this rare pediatric tumor.

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