Molecular Profile Changes in Patients with Castrate-Resistant Prostate Cancer Pre- and Post-Abiraterone/Prednisone Treatment.

Hugues Sicotte,Krishna R Kalari,Sisi Qin,Scott M Dehm,Vipul Bhargava,Michael Gormley,Winston Tan,Jason P Sinnwell,David W Hillman,Ying Li,Peter T Vedell,Rachel E Carlson,Alan H Bryce, Raphael E Jimenez,Richard M Weinshilboum,Manish Kohli,Liewei Wang

Molecular cancer research : MCR（2022）

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摘要

Finally, we identified candidates drugs to reverse AA/P resistance: topoisomerase inhibitors and drugs targeting the cell cycle via the MYC/AURKA/AURKB/TOP2A and/or PI3K_AKT_MTOR pathways.

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关键词

prostate cancer,molecular profile changes,castrate-resistant,post-abiraterone

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