Calcium Channel Blockers: Clinical Outcome Associations with Reported Pharmacogenetics Variants in 32,000 Patients

Deniz Türkmen,Jane A H Masoli,João Delgado,Chia-Ling Kuo,Jack Bowden,David Melzer,Luke C Pilling

GENETIC EPIDEMIOLOGY（2022）

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摘要

Patients with common genetic variants in NUMA1, CYP3A5 and RYR3 had increased adverse clinical outcomes. Work is needed to establish whether outcomes of dCCB prescribing could be improved by prior knowledge of pharmacogenetics variants supported by clinical evidence of association with adverse events.

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calcium-channel blockers,epidemiology,genetics,hypertension,pharmacogenomics

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